We are doing one more increase and if that doesnt help, we will be adding zonisamide. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). Not grass grazing either. (145 Reviews) $15.50 - $31.09. Now we are waiting for the verdict: whether its an infection in his bladder or stones. You seem like an idiot. Did the tremors ever stop? I feel so sad for you Camelia. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. I returned to vet next day with him and was advised he was ok. Hi Laura, How is you pup doing one after getting off simparica? My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. She is shaking and panting heavy. What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. We rescued another dog. Let us now look at possible side effects when administering Simparica. What do I do? My vet prescribed my 16 week old puppy this drug because of a skin irritation. I hope it is better. Im going to keep a close watch on him over the next few days. He said it would take care of ticks and Trifexis doesn't. Started downhill health issues with initial dose. For: Vet took blood yesterday should get results today. If she continues I will be going to the vet. Im now scared half to death. Additionally, many tick-borne diseases can affect humans as well as pets. Possible side effects: Vomiting, diarrhea (if these . like she wants me to fix it. She had terrible watery diarrhea and is not interested in eating. Just wondering? He has trouble raising his leg to urinate. She was being seen by her regular vet and was put on antibiotics. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. well my lola went into labor xmas day. Our two year old dog took the same thing and thank god she has no symptoms. Thursday morning was an awful beginning of the day for our boy. Hi, any chance you did a spinal tap? For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. Is it effective? Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials. I will NEVER give this drug to my dogs! I only stumbled on the side effects of this drug via a post on a Spinone group. Same here! my vet recommended this for both my yorkies. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. I put water with electrolytes by his cage & food . Is there hope? He isnt losing weight but really looks horrible. If not, we had some success with symptom management using Prednisone. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. They keep telling me that she would have been sick from the first pill, not just the 2nd. We are already close to $2000 in Vet bills not counting the poison we bought her. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. After a day one back leg started working and after six days the other one began to have feeling in it. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. I am SOOO angry! I advise all pet owners to know the side effects. Now his tail looks like a rat tail. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Once again peed in my office on Saturday. Poor baby has had vomiting and diarrhoea ever since. This crap is poison! I did and they said they are going to report it to the FDA. His motor skills have been affected and hes been losing weight even though he eats heartily. We got to the Animal Hospital . Simparica TRIO requires a prescription from your veterinarian. You don't think I'm going to continue with this poison. Revolution has been around decades with less incidents of animal reactions. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. She is absolutely miserable and we're hoping she makes it. Be aware! Last year I gave them this but didn't notice any issues. And how long for this sheet to get out of the dogs system??? On 01/07/21, we gave our 11 year old black lab, Rawley, a 2nd dose of Simparico TRIO. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). I assume it's getting out of his system. Still waiting to find out of she has progressed. About 11 months ago our vet recommended Simparica Trio. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. The site is secure. He is a 6 month old Bloodhound so they are always hyper. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. I thought right away it must be the new meds! So this month. I wish I had seen this post first. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. Now her dog is very sick and she has to take the dog to the vet every day in the past week. They would clear up after a round of antibiotics but would return the next month. He is my first dog, he is 5yrs old now, and this is all new. I say yes! I am more than upset, I am effing pissed, my poor little boy. My dog died from it after one dose within 24 hours. They still will not consider that it is the Simparica Trio. Hoping you are the lucky ones!! My personal dog has had no issues at all, and she's been on it for nearly two years. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. In some dogs, Simparica may cause abnormal neurologic signs such as: Tremors and Seizures. Itching has decreased immensely. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. This morning was the first morning he left water in his bowl. I paid $120 for 6 months of poison. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Another call to vet asking for an appt - seems like an an emergency now? I'm so scared. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. I don't want another animal harmed by this stuff, one animal is one to many. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. Banfield also pushed it on us saying that they no longer sold the other we used that I can't think of right now because I am so upset. This sounds so scary. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. This junk needs to be pulled from the market. I should have kept with my gut feeling about any of these oral meds. She is still in the vet since 3am. Never happened before. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. All the swelling went down immediately and the itching went away too. Maybe dont have a dog. I argued with the vet that this is poison and she said why would I give your dog poison? But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. Today the seizure like attack happened even though he is on the steroids. Our baby isnt the same at all since his one and only dose of Simparica. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. I gave simparica trio to my 10-year-old Havanese. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Side effects The contra indication is important to know before you utilize the simparica. The cardiologist found no heart condition that would cause this. Went to a different vet, within minutes he found a large mass on my Poms abdomen. Each medication combats different pests. Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. I hate that I did this to her and I hate that the Vet does not seem to care. I'm so upset. In addition to the tremors, have you noticed any . Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. CET HEXtra Chews. We think that the drug is the cause of the seizures . That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. I used to use revolution but they dont cover ticks as well. Has odd agitated swallowing when not eating anything. Is it just me or does it seem like everyone is in this together? It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . She was terrified and we were too. Bella is a very anxious dog and is my husbands shadow. She also started with ear infections. I came across this site and read so much about symptoms that I now realize he has been having. I wish I would have seen this site before I gave it my Matty. They must get some kind of monetary bonus for only selling Simparica. Vet gave her a shot which stopped it. I feel like it was a massive overdose. Took him back to the vet. Stopped meds and he has had 3 more seizures since. Stressing out now. I'll continue to watch her. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Any tips on how to flush it from her system ? 300+ Cute Cat Names for Every Kind of Kitty. I am starting to get scared they are both 80 lbs and the other dog is. Im certain that its the simparica. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. (147 Reviews) $18.38 - $44.91. Dogs Naturally Market is a good source to check out. I am hoping it is almost all out of her system. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Sorry, cant see you for 4 days. She started it on 7/22. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Two weeks after I made the post above our girl started having seizures and we had to put her down. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. He had to be put to sleep and Im devastated. Started in February and within a couple of weeks ears started twitching. I feel like she's been an experiment to make others money. I to also gave my best friend Simparica as recommended by the vet. Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. I just wish I could find a vet who honestly loves my animals as much as I do. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. Buddy 8 year old male Boxer formerly energetic and playful. How is ur puppy? I would, still boil chicken, carrots, potatoes for his meals. Don't trust your vet, do your own research. The next day Bellas stools were quite soft but still had some structure. Severity: Severity is mild to moderate to severe Read more. Trifexis and Simparica are available only with a prescription from your veterinarian. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. Just our own personal experience but I won't get burned again! It seems to be clearing up with Rx eye drops. This is lethal medication for dogs and should be taken off the market now. I called the breeder, and she said some vaccines and heartworm meds can cause neurological issues. I do believe it caused her blindness. My French bulldog 2 years olds had a second attack in 3 days. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. Was checking out before using . Initially I noticed minor tremors and twitching when he slept or was just relaxing. I'm at a loss We had same issues. Has started to stumble and sleeps 10 to 12 hours at a time. Hi, I was just wondering how long you continued on with the steroids with your puppy. My dog has had 3 seizures in the past from wearing a flea collar. This medication must really be strong to do Flea tic and heart worm etc. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. The vet suggested Simparico trio . My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! Then on day 5 my poor dog just couldnt move. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. Then things got progressively worse. Hello! I just hope and pray she gets better. Possible Side Effects. With Entyce she is getting her appetite back and seems a little better. Mine passed within 24 hours of the first dose. 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